Teratogen update: antithyroid drugs?methimazole, carbimazole, and propylthiouracil
نویسندگان
چکیده
منابع مشابه
Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil.
Thyrotoxicosis occurs in about 0.2% of pregnancies and is caused most frequently by Graves disease (Burrow, ’85; Kriplani et al., ’94). Graves disease is an autoimmune disorder characterized by the production of antibodies, immunoglobulins of the IgG class, directed against thyroid stimulating hormone (TSH) receptors (Shoenfeld and Schwartz, ’84). This results in the excess production of thyroi...
متن کاملPropylthiouracil, and methimazole, and carbimazole-related hepatotoxicity.
INTRODUCTION Propylthiouracil (PTU) has been used for the treatment of hyperthyroidism since the 1940s, but over the years reports of significant hepatotoxicity have come forth, particularly in children. This led to a black box warning being issued by the US FDA in 2009, followed by a similar warning by the European Medicines Agency and the United Kingdom Medicines and Healthcare Regulatory Age...
متن کاملChange from propylthiouracil to carbimazole proves fatal.
Recent changes in New Zealand have altered the availability of propylthiouracil. It is no longer a ‘funded’ medication but is only available via an ‘Exceptional Circumstances’ application to the Pharmaceutical Management Agency (PHARMAC). Because of this a number of patients in our practice were changed from propylthiouracil to carbimazole. We report a patient who developed agranulocytosis foll...
متن کاملTeratogen update: iodine deficiency, a community teratogen.
In the last decade, iodine deficiency disorders (IDD) have become recognized as the most common preventable cause of mental retardation worldwide. Iodine deficiency interferes severely with prenatal and postnatal growth and neurologic development of individuals. It has condemned tens of millions of children to cretinism—characterized by mental and growth retardation, rigid spastic motor disorde...
متن کاملTeratogen update: inorganic arsenic.
BACKGROUND Inorganic arsenic has been used by many laboratories to study the pathogenesis of exencephaly in rodents. These studies, which used predominantly injection exposures, coupled with the paucity of epidemiology data, resulted in the erroneous inference that inorganic arsenic should be considered a human teratogen. METHODS This study assembles and assesses literature analyses of older ...
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ژورنال
عنوان ژورنال: Teratology
سال: 2002
ISSN: 0040-3709,1096-9926
DOI: 10.1002/tera.1096